Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation

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Double Antiplatelet Therapy After Drug-Eluting Stent Implantation

Ignacio Ferreira-González, MD, PHD,*† Josep R. Marsal, BSC,*†‡ Aida Ribera, PHD,*† Gaietà Permanyer-Miralda, MD, PHD,*† Bruno Garcı́a-Del Blanco, MD,* Gerard Martı́, MD,* Purificación Cascant, RN,*† Mónica Masotti-Centol, MD, PHD,§ Xavier Carrillo, MD, Josepa Mauri, PHD, Nuria Batalla, MD,¶ Eduard Larrousse, MD,# Eva Martı́n, MD,** Antonio Serra, MD,†† José Ramón Rumoroso, MD,‡‡ Rafael Ruiz-Salmer...

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Antiplatelet therapy and stent thrombosis after sirolimus-eluting stent implantation.

BACKGROUND The influences of antiplatelet therapy discontinuation on the risk of stent thrombosis and long-term clinical outcomes after drug-eluting stent implantation have not yet been addressed adequately. METHODS AND RESULTS In an observational study in Japan, 2-year outcomes were assessed in 10 778 patients undergoing sirolimus-eluting stent implantation. Data on status of antiplatelet th...

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Individualization of dual antiplatelet therapy duration after drug-eluting stent implantation: paradigm and reality.

The use of drug-eluting stents (DES) results in a dramatic reduction in restenosis and represents one of the major advances in interventional cardiology. Yet, a reduction in death and myocardial infarction could not be shown with these devices; instead there were concerns about an excess of late thrombotic events compared with bare metal stents (BMS). The key underlying pathophysiological mecha...

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Diverticular bleeding complicating dual antiplatelet therapy after drug-eluting stent implantation

Acute lower gastrointestinal bleeding is defined as a bleeding situation in which blood loss has been occurring for less than 3 days resulting in haemodynamic instability, anaemia, or the need for blood transfusion. Diverticula and angiectasias are the most frequent sources of bleeding. Malignancy, inflammatory bowel disease, non-steroidal anti-inflammatory drugs, infectious colitis, ischaemia,...

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Optimal duration of dual antiplatelet therapy after drug eluting stent implantation: a network meta-analysis

OBJECTIVE There has been much debate regarding the optimal duration of dual antiplatelet therapy (DAPT) cover after drug eluting stent (DES) implantation. We aimed to assess the relative benefits of shorter and longer durations of DAPT coverage. METHODS We performed a network meta-analysis (NMA) of all the randomized clinical trials (RCT) comparing different time durations of DAPT cover. RE...

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ژورنال

عنوان ژورنال: Journal of the American College of Cardiology

سال: 2012

ISSN: 0735-1097

DOI: 10.1016/j.jacc.2012.08.003